Virgin and Child with Saint Anne and Saints Francis and Lidwina, with Donors (Anna Selbdritt) by Master of the Saint John Panels (1490 - 1500) - Public Domain Catholic Painting

A Madonna is a representation of Mary, either alone or with her child Jesus. These images are central icons for both the Catholic and Orthodox churches. The word is from Italian ma donna 'my lady'. Wikipedia

Francis of Assisi, venerated as Saint Francis of Assisi, also known in his ministry as Francesco, was an Italian Catholic friar, deacon, mystic, and preacher. He founded the men's Order of Friars Minor, the women's Order of St. Clare, the Third Order of St. Francis and the Custody of the Holy Land. Wikipedia

According to apocryphal Christian and Islamic tradition, Saint Anne was the mother of Mary and the maternal grandmother of Jesus. Mary's mother is not named in the canonical gospels. Wikipedia

Lidwina was a Dutch mystic who is honored as a saint by the Catholic Church. She is also thought to be one of the first documented cases of multiple sclerosis. Wikipedia